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Article

Analysis of DNA variants in miRNAs and miRNA 3'UTR binding sites in female infertility patients.

Laboratory investigation; a journal of technical methods and pathology - 1 Apr 2021

Tyc Katarzyna M, Wong Anthony, Scott Richard T, Tao Xin, Schindler Karen, Xing Jinchuan

Abstract excerpt

Early human embryogenesis relies on maternal gene products accumulated during oocyte growth and maturation, until around day-3 post-fertilization when human zygotic genome activation occurs. The maternal-to-zygotic transition (MZT) is a tightly coordinated process of selective maternal transcript clearance and new zygotic transcript production. If MZT is disrupted, it will lead to developmental arrest and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33070169
DOI: 10.1038/s41374-020-00498-x
PMCID: PMC7987713

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