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Article

Inhibition of CDK4/6 and autophagy synergistically induces apoptosis in t(8;21) acute myeloid leukemia cells.

International journal of hematology - 1 Feb 2021

Nakatani Kana, Matsuo Hidemasa, Harata Yutarou, Higashitani Moe, Koyama Asami, Noura Mina, Nishinaka-Arai Yoko, Kamikubo Yasuhiko, Adachi Souichi

Abstract excerpt

The t(8;21) translocation is the most common cytogenetic abnormality in acute myeloid leukemia (AML). Although t(8;21) AML patients have a relatively favorable prognosis, relapse is a frequent occurrence, underscoring the need to develop novel therapeutic approaches. Here, we showed that t(8;21) AML is characterized by frequent mutation and overexpression of CCND2. Analysis of 19 AML cell lines showed that...

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Identifiers

PMID: 33068248
DOI: 10.1007/s12185-020-03015-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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