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Specific Gene Co-variation Acts Better Than Number of Concomitant Altered Genes in Predicting EGFR-TKI Efficacy in Non-small-cell Lung Cancer.

Clinical lung cancer - 1 Jan 2021

Zhu Yan-Juan, Qu Xin, Zhan Dan-Dan, Chen Hui-Hui, Li Hai-Peng, Liu Li-Rong, Chen Xian, Liu Yi-Hong, Li Yong, Bai Jian-Ping, Ye Sheng, Zhang Hai-Bo

Abstract excerpt

BACKGROUND: There occurs huge heterogeneity in clinical outcomes for patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs). The purpose of this study was to indicate genetic biomarkers predicting primary resistance of EGFR-TKIs in these patients. PATIENTS AND METHODS: Using a next-generation sequencing panel with...

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Identifiers

PMID: 33067127
DOI: 10.1016/j.cllc.2020.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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