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Genetic source completeness of HIV-1 circulating recombinant forms (CRFs) predicted by multi-label learning.

Bioinformatics (Oxford, England) - 5 May 2021

Tang Runbin, Yu Zuguo, Ma Yuanlin, Wu Yaoqun, Phoebe Chen Yi-Ping, Wong Limsoon, Li Jinyan

Abstract excerpt

MOTIVATION: Infection with strains of different subtypes and the subsequent crossover reading between the two strands of genomic RNAs by host cells' reverse transcriptase are the main causes of the vast HIV-1 sequence diversity. Such inter-subtype genomic recombinants can become circulating recombinant forms (CRFs) after widespread transmissions in a population. Complete prediction of all the subtype sources of a...

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PMID: 33063094
DOI: 10.1093/bioinformatics/btaa887

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