Article
Two Cases With Features of Lymphocyte Variant Hypereosinophilic Syndrome With STAT3 SH2 Domain Mutations.
The American journal of surgical pathology - 1 Feb 2021
Fernandez-Pol Sebastian, Petersen Bruce, Murphy Jo-Ellen, Oak Jean S, Wang Erica B K, Rieger Kerri E, Kim Youn H, Khodadoust Michael S, Suarez Carlos J
Abstract excerpt
Lymphocyte variant hypereosinophilic syndrome (LV-HES) is a rare cause of eosinophilia that is due to eosinophilipoietic cytokine production by an immunophenotypically abnormal T-cell clone. The molecular pathogenesis of this disorder is largely unknown and only 1 case of LV-HES with a pathogenic STAT3 mutation has been described thus far. Here we report 2 cases of LV-HES with STAT3 SH2 domain mutations. These...
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