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Article

High frequency of variants in genes associated with primary immunodeficiencies in patients with rheumatic diseases with secondary hypogammaglobulinaemia.

Annals of the rheumatic diseases - 1 Mar 2021

Sogkas Georgios, Dubrowinskaja Natalia, Adriawan Ignatius Ryan, Anim Manfred, Witte Torsten, Schmidt Reinhold E, Atschekzei Faranaz

Abstract excerpt

OBJECTIVES: Treatment of rheumatic diseases requires immunomodulatory agents which can compromise antibody production. However, even in case of agents directly targeting B cells, a minority of patients develop hypogammaglobulinaemia, suggesting a genetic predisposition, which has not been investigated so far. The phenotypic overlap between primary immunodeficiency disorders (PIDs) and rheumatic diseases suggests...

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PMID: 33046446
DOI: 10.1136/annrheumdis-2020-218280

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