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Article

Circadian Gene Expression Rhythms During Critical Illness

7 Oct 2020

Abstract excerpt

OBJECTIVES: Core clock genes regulate tissue-specific transcriptome oscillations that synchronize physiologic processes throughout the body, held in phase by the central circadian rhythm. The central circadian rhythm rapidly dampens with onset of critical illness, but the effect of critical illness on gene expression oscillations is unknown. The objective of this study was to characterize the rhythmicity and...

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PMID: 33031153
DOI: 10.1097/ccm.0000000000004697

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