Article
Sex Does Not Influence Visual Outcomes After Blast-Mediated Traumatic Brain Injury but IL-1 Pathway Mutations Confer Partial Rescue.
Investigative ophthalmology & visual science - 1 Oct 2020
Evans Lucy P, Boehme Nickolas, Wu Shu, Burghardt Elliot L, Akurathi Abhigna, Todd Brittany P, Newell Elizabeth A, Ferguson Polly J, Mahajan Vinit B, Dutca Laura M, Harper Matthew M, Bassuk Alexander G
Abstract excerpt
Purpose: In a mouse model of blast-mediated traumatic brain injury (bTBI), interleukin-1 (IL-1)-pathway components were tested as potential therapeutic targets for bTBI-mediated retinal ganglion cell (RGC) dysfunction. Sex was also evaluated as a variable for RGC outcomes post-bTBI. Methods: Male and female mice with null mutations in genes encoding IL-1α, IL-1β, or IL-1RI were compared to C57BL/6J wild-type (WT)...
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