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Article

Modeling circadian regulation of ovulation timing: age-related disruption of estrous cyclicity.

Scientific reports - 7 Oct 2020

Ohara Takayuki, Nakamura Takahiro J, Nakamura Wataru, Tokuda Isao T

Abstract excerpt

The circadian clocks within the hypothalamic-pituitary-gonadal axis control estrous cycles in female rodents. The suprachiasmatic nucleus (SCN), where the central clock is located, generates daily signals to trigger surge release of luteinizing hormone (LH), which in turn induces ovulation. It has been observed in aged rodents that output from the SCN such as neuronal firing activity is declined, and estrous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33028871
DOI: 10.1038/s41598-020-73669-x
PMCID: PMC7541497

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