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Article

Dynamics of genomic and immune responses during primary immunotherapy resistance in mismatch repair-deficient tumors.

Cold Spring Harbor molecular case studies - 1 Oct 2020

Takahashi Nobuyuki, Rajapakse Vinodh N, Pongor Lorinc, Kumar Suresh, Tlemsani Camille, Erwin-Cohen Rebecca, Young Howard A, Hewitt Stephen, Wei Jun S, Khan Javed, Villarino Alejandro V, Trepel Jane B, Thomas Anish

Abstract excerpt

Mismatch repair-deficient (dMMR) cancers generate a substantial number of immunogenic neoantigens, rendering them sensitive to immunotherapy. Yet, there is considerable variability in responses, and roughly one-half of dMMR cancers are refractory to immunotherapy. Here we study a patient with dMMR lung cancer refractory to immunotherapy. The tumor exhibited typical dMMR molecular features, including exceptionally...

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Identifiers

PMID: 33028646
DOI: 10.1101/mcs.a005678
PMCID: PMC7552928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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