Genetic Rescue of X-Linked Retinoschisis Mouse ( <i>Rs1</i> ^−/y ) Retina Induces Quiescence of the Retinal Microglial Inflammatory State Following AAV8- <i>RS1</i> Gene Transfer and Identifies Gene Networks Underlying Retinal Recovery

Abstract excerpt

To understand RS1 gene interaction networks in the X-linked retinoschisis (XLRS) mouse retina ( Rs1 −/y ), we analyzed the transcriptome by RNA sequencing before and after in vivo expression of exogenous retinoschisin ( RS1 ) gene delivered by AAV8. RS1 is a secreted cell adhesion protein that is critical for maintaining structural lamination and synaptic integrity of the neural retina. RS1 loss-of-function...