Article
Choosing the optimal population for a genome-wide association study: A simulation of whole-genome sequences from rice.
The plant genome - 1 Mar 2020
Hamazaki Kosuke, Kajiya-Kanegae Hiromi, Yamasaki Masanori, Ebana Kaworu, Yabe Shiori, Nakagawa Hiroshi, Iwata Hiroyoshi
Abstract excerpt
A genome-wide association study (GWAS) needs to have a suitable population. The factors that affect a GWAS (e.g. population structure, sample size, and sequence analysis and field testing costs) need to be considered. Mixed populations containing subpopulations of different genetic backgrounds may be suitable populations. We conducted simulation experiments to see if a population with high genetic diversity, such...
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