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Article

Antigenic Variability.

Frontiers in immunology - 1 Jan 2020

Mosa Alexander I

Abstract excerpt

Protective vaccines for hypervariable pathogens are urgently needed. It has been proposed that amputating highly variable epitopes from vaccine antigens would induce the production of broadly protective antibodies targeting conserved epitopes. However, so far, these approaches have failed, partially because conserved epitopes are occluded in vivo and partially because co-localizing patterns of immunodominance and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33013870
DOI: 10.3389/fimmu.2020.02057
PMCID: PMC7516049

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