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Development of a longitudinal two-biomarker algorithm for early detection of ovarian cancer in women with BRCA mutations.

Gynecologic oncology - 1 Dec 2020

Lentz Scott E, Powell C Bethan, Haque Reina, Armstrong Mary Anne, Anderson Meredith, Liu Yiling, Jiang Wenqing, Chillemi Giulia, Shaw Sally, Alvarado Monica M, Kushi Lawrence H, Skates Steven J

Abstract excerpt

OBJECTIVE: To develop a longitudinal algorithm combining two biomarkers, CA125 and HE4, for early detection of ovarian cancer in women with BRCA mutations. METHODS: Women with BRCA mutations and intact ovaries were invited to participate in a novel ovarian cancer early detection prospective study. The Risk of Ovarian Cancer Algorithm (ROCA) identifying significant increases above each woman's baseline in serum...

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Identifiers

PMID: 33012551
DOI: 10.1016/j.ygyno.2020.09.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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