Article
ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men: a genome-wide G × E interaction analysis.
Scientific reports - 1 Oct 2020
Sutoh Yoichi, Hachiya Tsuyoshi, Suzuki Yuji, Komaki Shohei, Ohmomo Hideki, Kakisaka Keisuke, Wang Ting, Takikawa Yasuhiro, Shimizu Atsushi
Abstract excerpt
Liver tests (LT), especially to measure AST, ALT and GGT levels, are widely used to evaluate the risk of alcohol-related liver disease (ALD). In this study, we investigated the potential genetic factors that modulate the association between LTs and alcohol consumption. We conducted a genome-wide interaction meta-analysis in 7856 Japanese subjects from Tohoku Medical Megabank Community-Based Cohort (TMM...
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