Article
Recurrent ZNF83-E293V Mutation Promotes Bladder Cancer Progression through the NF-κB Pathway via Transcriptional Dysregulation of S100A8.
Molecular therapy : the journal of the American Society of Gene Therapy - 6 Jan 2021
Lyu Zhao J, Wang Ying, Huang Jin L, Chen Miao, Wu Sha Y, Yan Qian, Zhang Yu, Tang Ying, Jiang Chen, Li Lei, Jia Yi Z, Liu Yu C, Mei Hong B, Wang Feng, Li Ren H, Chen Ya C, Lin Xiang, Cai Zhi M, Guan Xin Y
Abstract excerpt
Urothelial carcinoma (UC) is the predominant form of bladder cancer. Significant molecular heterogeneity caused by diverse molecular alterations brings about large variations in the response to treatment in UC. An improved understanding of the genetic mechanisms underlying the development and progression of UC is essential. Through deep analysis of next-generation sequencing data of 99 UC patients, we found that...
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