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Article

Discovery of TITIN Gene Truncating Variant Mutations and 5-Year Outcomes in Patients With Nonischemic Dilated Cardiomyopathy.

The American journal of cardiology - 15 Dec 2020

Anderson Jeffrey L, Christensen G Bryce, Escobar Helaman, Horne Benjamin D, Knight Stacey, Jacobs Victoria, Afshar Kia, Hebl Virginia B, Muhlestein Joseph B, Knowlton Kirk U, Carlquist John F, Nadauld Lincoln D

Abstract excerpt

Genetic factors play an important role in nonischemic dilated cardiomyopathy (NIDC). However, prime opportunities remain for genetic discovery and prognostic understanding. TITIN gene truncating variant mutations (TTNtv) are of interest because of their frequent appearance in NIDC series. We sought to discover known and novel TTNtv mutations in a NIDC cohort and assess 5-year outcomes. Patients with NIDC entered...

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PMID: 32998006
DOI: 10.1016/j.amjcard.2020.09.026

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