Article
PCD Detect: enhancing ciliary features through image averaging and classification.
American journal of physiology. Lung cellular and molecular physiology - 1 Dec 2020
Shoemark Amelia, Pinto Andreia L, Patel Mitali P, Daudvohra Farheen, Hogg Claire, Mitchison Hannah M, Burgoyne Thomas
Abstract excerpt
Primary ciliary dyskinesia (PCD) is an inherited disorder of the motile cilia. Early accurate diagnosis is important to help prevent lung damage in childhood and to preserve lung function. Confirmation of a diagnosis traditionally relied on assessment of ciliary ultrastructure by transmission electron microscopy (TEM); however, >50 known PCD genes have made the identification of biallelic mutations a viable...
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