Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019.

doi:10.1093/cid/ciaa1474

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Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 5 Oct 2021

Martinot Martin, Jary Aude, Fafi-Kremer Samira, Leducq Valentin, Delagreverie Heloise, Garnier Marc, Pacanowski Jérôme, Mékinian Arsène, Pirenne France, Tiberghien Pierre, Calvez Vincent, Humbrecht Catherine, Marcelin Anne-Geneviève, Lacombe Karine

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered virus for which remdesivir is the only antiviral available. We report the occurrence of a mutation in RdRP (D484Y) following treatment with remdesivir in a 76-year-old female with post-rituximab B-cell immunodeficiency and persistent SARS-CoV-2 viremia. A cure was achieved after supplementation with convalescent plasma.

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PMID: 32986807
DOI: 10.1093/cid/ciaa1474
PMCID: PMC7543308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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