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Article

Mechanisms of Bone Fragility: From Osteogenesis Imperfecta to Secondary Osteoporosis

10 Jan 2021

Abstract excerpt

Bone material strength is determined by several factors, such as bone mass, matrix composition, mineralization, architecture and shape. From a clinical perspective, bone fragility is classified as primary (i.e., genetic and rare) or secondary (i.e., acquired and common) osteoporosis. Understanding the mechanism of rare genetic bone fragility disorders not only advances medical knowledge on rare diseases, it may...

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PMID: 33435159
DOI: 10.3390/ijms22020625

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