RNA-Seq profiling of microdissected glomeruli identifies potential biomarkers for human IgA nephropathy

Abstract excerpt

Few studies have examined gene expression changes occurring in the glomeruli of IgA nephropathy (IgAN) using a sensitive transcriptomic profiling method such as RNA sequencing (RNA-Seq). We collected glomeruli from biopsy specimens from patients with IgAN with relatively preserved kidney function (estimated glomerular filtration rate ≥ 60 mL·min−1·1.73 m−2and urine protein-to-creatinine ratio < 3 g/g) and from...

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