Article
IDH1/2 mutations in acute myeloid leukemia patients and risk of coronary artery disease and cardiac dysfunction-a retrospective propensity score analysis.
Leukemia - 1 May 2021
Kattih Badder, Shirvani Amir, Klement Piroska, Garrido Abel Martin, Gabdoulline Razif, Liebich Alessandro, Brandes Maximilian, Chaturvedi Anuhar, Seeger Timon, Thol Felicitas, Göhring Gudrun, Schlegelberger Brigitte, Geffers Robert, John David, Bavendiek Udo, Bauersachs Johann, Ganser Arnold, Heineke Joerg, Heuser Michael
Abstract excerpt
Clonal hematopoiesis of indeterminate potential (CHIP) is linked to leukemia gene mutations and associates with an increased risk for coronary artery disease and poor prognosis in ischemic cardiomyopathy. Two recurrently mutated genes in CHIP and adult acute myeloid leukemia (AML) encode for isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2). Global expression of mutant IDH2 in transgenic mice-induced dilated...
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