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A Single-Cell RNA Expression Map of Human Coronavirus Entry Factors

1 Sept 2020

Abstract excerpt

To predict the tropism of human coronaviruses, we profile 28 SARS-CoV-2 and coronavirus-associated receptors and factors (SCARFs) using single-cell transcriptomics across various healthy human tissues. SCARFs include cellular factors both facilitating and restricting viral entry. Intestinal goblet cells, enterocytes, and kidney proximal tubule cells appear highly permissive to SARS-CoV-2, consistent with clinical...

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PMID: 32946807
DOI: 10.1016/j.celrep.2020.108175

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