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Article

Single-cell RNA-seq reveals the immune escape and drug resistance mechanisms of mantle cell lymphoma

1 Jan 2020

Abstract excerpt

Objective: Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin lymphoma (NHL) with high heterogeneity and a high recurrence rate. How heterogenous cell populations contribute to relapse remains to be elucidated. Methods: We performed single cell RNA sequencing (scRNA-seq) on approximately 4,000 bone marrow cells sampled from one patient with multidrug resistant MCL. We identified 10 subpopulations...

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PMID: 32944402
DOI: 10.20892/j.issn.2095-3941.2020.0073

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