A gene signature that distinguishes conventional and leukemic nonnodal mantle cell lymphoma helps predict outcome.

doi:10.1182/blood-2018-03-838136

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Article

A gene signature that distinguishes conventional and leukemic nonnodal mantle cell lymphoma helps predict outcome.

Blood - 26 Jul 2018

Clot Guillem, Jares Pedro, Giné Eva, Navarro Alba, Royo Cristina, Pinyol Magda, Martín-Garcia David, Demajo Santiago, Espinet Blanca, Salar Antonio, Ferrer Ana, Muntañola Ana, Aymerich Marta, Rauert-Wunderlich Hilka, Jaffe Elaine S, Connors Joseph M, Gascoyne Randy D, Delabie Jan, López-Guillermo Armando, Ott German, Wright George W, Staudt Louis M, Rosenwald Andreas, Scott David W, Rimsza Lisa M, Beà Sílvia, Campo Elías

Abstract excerpt

Mantle cell lymphoma (MCL) is an aggressive B-cell malignancy, but some patients have a very indolent evolution. This heterogeneous course is related, in part, to the different biological characteristics of conventional MCL (cMCL) and the distinct subgroup of leukemic nonnodal MCL (nnMCL). Robust criteria to distinguish these MCL subtypes and additional biological parameters that influence their evolution are not...

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PMID: 29769262
DOI: 10.1182/blood-2018-03-838136
PMCID: PMC6071558

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