Multi-omic studies on missense PLG variants in families with otitis media.

doi:10.1038/s41598-020-70498-w

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Multi-omic studies on missense PLG variants in families with otitis media.

Scientific reports - 14 Sept 2020

Bootpetch Tori C, Hafrén Lena, Elling Christina L, Baschal Erin E, Manichaikul Ani W, Pine Harold S, Szeremeta Wasyl, Scholes Melissa A, Cass Stephen P, Larson Eric D, Chan Kenny H, Ishaq Rafaqat, Prager Jeremy D, Shaikh Rehan S, Gubbels Samuel P, Yousaf Ayesha, Wine Todd M, Bamshad Michael J, Yoon Patricia J, Jenkins Herman A, Nickerson Deborah A, Streubel Sven-Olrik, Friedman Norman R, Frank Daniel N, Einarsdottir Elisabet, Kere Juha, Riazuddin Saima, Daly Kathleen A, Leal Suzanne M, Ryan Allen F, Mattila Petri S, Ahmed Zubair M, Sale Michele M, Chonmaitree Tasnee, Santos-Cortez Regie Lyn P

Abstract excerpt

Otitis media (OM), a very common disease in young children, can result in hearing loss. In order to potentially replicate previously reported associations between OM and PLG, exome and Sanger sequencing, RNA-sequencing of saliva and middle ear samples, 16S rRNA sequencing, molecular modeling, and statistical analyses including transmission disequilibrium tests (TDT) were performed in a multi-ethnic cohort of 718...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ear, Middle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomics

Share to Microbiota

Share to Mutation, Missense

Share to Otitis Media

Share to Pedigree

Share to Plasminogen

Share to Saliva

Source

Open in PubMed Open full text

Identifiers

PMID: 32929111
DOI: 10.1038/s41598-020-70498-w
PMCID: PMC7490366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-omic studies on missense PLG variants in families with otitis media.PMID 32929111Read ↗

Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5 variants.Semantic proximity Read ↗

Replication of missense OTOG gene variants in a Brazilian cohort of Menière’s DiseaseSemantic proximity Read ↗

Genome-wide association study to identify the genetic determinants of otitis media susceptibility in childhood.Semantic proximity Read ↗

Genetic contributors to otitis media: agnostic discovery approaches.Semantic proximity Read ↗

Genetic susceptibility to otitis media in childhood.Semantic proximity Read ↗

Rare Variants in the <i>OTOG</i> Gene Are a Frequent Cause of Familial Meniere’s DiseaseSemantic proximity Read ↗

An overload of missense variants in the OTOG gene may drive a higher prevalence of familial Meniere disease in the European population.Semantic proximity Read ↗

An overload of missense variants in the OTOG gene may drive a higher prevalence of familial Meniere disease in the European descendant populationSemantic proximity Read ↗

Panel 3: Genomics, precision medicine and targeted therapies.Semantic proximity Read ↗

Excess of rare missense variants in hearing loss genes in sporadic Meniere diseaseSemantic proximity Read ↗

Excess of Rare Missense Variants in Hearing Loss Genes in Sporadic Meniere DiseaseSemantic proximity Read ↗

Genetics of otitis media.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.