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Intrinsic Heart Regeneration in Adult Vertebrates May be Strictly Limited to Low‐Metabolic Ectotherms

11 Sept 2020

Abstract excerpt

The heart has a high-metabolic rate, and its "around-the-clock" vital role to sustain life sets it apart in a regenerative setting from other organs and appendages. The landscape of vertebrate species known to perform intrinsic heart regeneration is strongly biased toward ectotherms-for example, fish, salamanders, and embryonic/neonatal ectothermic mammals. It is hypothesized that intrinsic heart regeneration is...

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PMID: 32914411
DOI: 10.1002/bies.202000054

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