Article
First report of the spectrum of δ-globin gene mutations among women of reproductive age in Fujian area-Discrimination of δ-thalassemia, α-thalassemia, and Iron Deficiency Anemia.
Journal of clinical laboratory analysis - 1 Nov 2020
Chen Meihuan, Huang Hailong, Chen Lingji, Lin Na, Zhang Min, Lin Yuan, Xu Liangpu
Abstract excerpt
BACKGROUND: Low HbA2 level is an underlying of δ-thalassemia, α-thalassemia, and IDA. Interactions of these disorders can generate a wide spectrum of phenotype, which will pose diagnostic conundrum for clinical assessment, carrier screening, and genetic counseling. METHODS: Subjects with HbA2 levels below 2.0% with normal or reduced hematological parameters were recruited for further investigation. δ-globin gene...
Topics
- Adolescent
- Adult
- Anemia, Iron-Deficiency
- China
- Cross-Sectional Studies
- Female
- Humans
- Middle Aged
- Molecular Epidemiology
- Mutation
- Young Adult