Article
Construction and efficacy evaluation of novel swine leukocyte antigen (SLA) class I and class II allele-specific poly-T cell epitope vaccines against porcine reproductive and respiratory syndrome virus.
The Journal of general virology - 1 Nov 2020
Tian Debin, Subramaniam Sakthivel, Heffron C Lynn, Mahsoub Hassan M, Sooryanarain Harini, Wang Bo, Cao Qian M, Hassebroek Anna, LeRoith Tanya, Foss Dennis L, Calvert Jay G, Meng Xiang-Jin
Abstract excerpt
Porcine reproductive and respiratory syndrome virus (PRRSV) causes an economically important global swine disease. Here we report the development of subunit PRRSV-2 vaccines by expressing swine leucocyte antigen (SLA) class I and class II allele-specific epitope antigens in a robust adenovirus vector. SLA I-specific CD8 and SLA II-specific CD4 T cell epitopes of PRRSV-2 NADC20 were predicted in silico. Stable...
Topics
- Alleles
- Animals
- Cell Line, Tumor
- Epitopes, T-Lymphocyte
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Lung
- Mice
- Peptides