Article
MicroRNA-211 Modulates the DUSP6-ERK5 Signaling Axis to Promote BRAFV600E-Driven Melanoma Growth In Vivo and BRAF/MEK Inhibitor Resistance.
The Journal of investigative dermatology - 1 Feb 2021
Lee Bongyong, Sahoo Anupama, Sawada Junko, Marchica John, Sahoo Sanjay, Layng Fabiana I A L, Finlay Darren, Mazar Joseph, Joshi Piyush, Komatsu Masanobu, Vuori Kristiina, de Jong Petrus R, Ray Animesh, Perera Ranjan J
Abstract excerpt
MicroRNAs (miRs) are important posttranscriptional regulators of cell fate in both normal and disease states. miR-211 has previously been shown to be a direct regulator of metabolism in BRAFV600E-mutant melanoma cells in vitro. Here, we report that miR-211 expression promotes the aggressive growth of BRAFV600E-mutant melanoma xenografts in vivo. miR-211 promoted proliferation through the posttranscriptional...
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