Article
NS5-V372A and NS5-H386Y variations are responsible for differences in interferon α/β induction and co-contribute to the replication advantage of Japanese encephalitis virus genotype I over genotype III in ducklings.
PLoS pathogens - 1 Sept 2020
Li Chenxi, Di Di, Huang Hui, Wang Xin, Xia Qiqi, Ma Xiaochun, Liu Ke, Li Beibei, Shao Donghua, Qiu Yafeng, Li Zongjie, Wei Jianchao, Ma Zhiyong
Abstract excerpt
Japanese encephalitis virus (JEV) genotype I (GI) replicates more efficiently than genotype III (GIII) in birds, and this difference is considered to be one of the reasons for the JEV genotype shift. In this study, we utilized duck embryo fibroblasts and domestic ducklings as in vitro and in vivo models of a JEV amplifying avian host to identify the viral determinants of the differing replication efficiency...
Topics
- Animals
- Antiviral Agents
- Ducks
- Encephalitis Virus, Japanese
- Encephalitis, Japanese
- Host-Pathogen Interactions
- Interferon-alpha
- Interferon-beta
- Mice
- Mutation