Article
Evaluation of molecular inversion probe versus TruSeq® custom methods for targeted next-generation sequencing.
PloS one - 1 Jan 2020
Almomani Rowida, Marchi Margherita, Sopacua Maurice, Lindsey Patrick, Salvi Erika, Koning Bart de, Santoro Silvia, Magri Stefania, Smeets Hubert J M, Martinelli Boneschi Filippo, Malik Rayaz R, Ziegler Dan, Hoeijmakers Janneke G J, Bönhof Gidon, Dib-Hajj Sulayman, Waxman Stephen G, Merkies Ingemar S J, Lauria Giuseppe, Faber Catharina G, Gerrits Monique M
Abstract excerpt
Resolving the genetic architecture of painful neuropathy will lead to better disease management strategies. We aimed to develop a reliable method to re-sequence multiple genes in a large cohort of painful neuropathy patients at low cost. In this study, we compared sensitivity, specificity, targeting efficiency, performance and cost effectiveness of Molecular Inversion Probes-Next generation sequencing (MIPs-NGS)...
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