Article
Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease-Brief Report.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2021
Small Aeron M, Huffman Jennifer E, Klarin Derek, Sabater-Lleal Maria, Lynch Julie A, Assimes Themistocles L, Sun Yan V, Miller Donald, Freiberg Matthew S, Morrison Alanna C, Rader Daniel J, Wilson Peter W F, Cho Kelly, Tsao Philip S, Chang Kyong-Mi, Smith Nicholas L, O'Donnell Christopher J, de Vries Paul S, Damrauer Scott M
Abstract excerpt
BACKGROUND AND OBJECTIVE: Peripheral artery disease (PAD) is the third most common form of atherosclerotic vascular disease and is characterized by significant functional disability and increased cardiovascular mortality. Recent genetic data support a role for a procoagulation protein variant, the factor V Leiden mutation, in PAD. The role of other hemostatic factors in PAD remains unknown. We evaluated the role...
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