Article
Searching for Predictors of Migraine Chronification: a Pilot Study of 1911A>G Polymorphism of TRPV1 Gene in Episodic Versus Chronic Migraine.
Journal of molecular neuroscience : MN - 1 Mar 2021
Yakubova Aliya, Davidyuk Yuriy, Tohka Jussi, Khayrutdinova Olga, Kudryavtsev Igor, Nurkhametova Dilyara, Kamshilin Alexei, Giniatullin Rashid, Rizvanov Albert
Abstract excerpt
Transient receptor potential vanilloid type 1 (TRPV1) receptors activated by heat and capsaicin are expressed in trigeminal nociceptive neurons and implicated in the generation of migraine pain. Genetic studies suggested that single-nucleotide polymorphism (SNP) 1911A>G (rs8065080), leading to amino acid substitution Ile585Val, in the TRPV1 gene affects functional activity of TRPV1 receptors and is involved in...
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