Article
Candidate-gene association study searching for genetic factors involved in migraine chronification.
Cephalalgia : an international journal of headache - 1 May 2015
Louter M A, Fernandez-Morales J, de Vries B, Winsvold B, Anttila V, Fernandez-Cadenas I, Vila-Pueyo M, Sintas C, van Duijn C M, Cormand B, Álvarez-Sabin J, Montaner J, Ferrari M D, van den Maagdenberg Amjm, Palotie A, Zwart J A, Macaya A, Terwindt G M, Pozo-Rosich P
Abstract excerpt
INTRODUCTION: Chronic migraine (CM) is at the severe end of the clinical migraine spectrum, but its genetic background is unknown. Our study searched for evidence that genetic factors are involved in the chronification process. METHODS: We initially selected 144 single-nucleotide polymorphisms (SNPs) from 48 candidate genes, which we tested for association in two stages: The first stage encompassed 262 CM...
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