Article
Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species.
PLoS biology - 1 Nov 2017
Lind Abigail L, Wisecaver Jennifer H, Lameiras Catarina, Wiemann Philipp, Palmer Jonathan M, Keller Nancy P, Rodrigues Fernando, Goldman Gustavo H, Rokas Antonis
Abstract excerpt
Filamentous fungi produce a diverse array of secondary metabolites (SMs) critical for defense, virulence, and communication. The metabolic pathways that produce SMs are found in contiguous gene clusters in fungal genomes, an atypical arrangement for metabolic pathways in other eukaryotes. Comparative studies of filamentous fungal species have shown that SM gene clusters are often either highly divergent or...
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