Article
Developmental exposure to near roadway pollution produces behavioral phenotypes relevant to neurodevelopmental disorders in juvenile rats.
Translational psychiatry - 17 Aug 2020
Berg Elizabeth L, Pedersen Lauren R, Pride Michael C, Petkova Stela P, Patten Kelley T, Valenzuela Anthony E, Wallis Christopher, Bein Keith J, Wexler Anthony, Lein Pamela J, Silverman Jill L
Abstract excerpt
Epidemiological studies consistently implicate traffic-related air pollution (TRAP) and/or proximity to heavily trafficked roads as risk factors for developmental delays and neurodevelopmental disorders (NDDs); however, there are limited preclinical data demonstrating a causal relationship. To test the effects of TRAP, pregnant rat dams were transported to a vivarium adjacent to a major freeway tunnel system in...
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