Article
Knockdown of lincRNA PADNA promotes bupivacaine-induced neurotoxicity by miR-194/FBXW7 axis.
Molecular medicine (Cambridge, Mass.) - 13 Aug 2020
Yuning Fan, Liang Chen, Tenghuan Wang, Zhenhua Nan, Shengkai Gong
Abstract excerpt
BACKGROUND: The aim of the study was to explore the function and mechanism of lincRNA PADNA in bupivacaine-induced neurotoxicity. METHODS: Mouse DRG neurons were cultured in vitro and treated with bupivacaine to establish a neurotoxicity model. Caspase3 activity, cell viability, and TUNEL assays were analyzed to assess the role of lincRNA PADNA. A dual-luciferase reporter assay was used to determine the binding...
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