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Article

Variants in Homologous Recombination Genes EXO1 and RAD51 Related with Premature Ovarian Insufficiency

9 Aug 2020

Abstract excerpt

CONTEXT: Premature ovarian insufficiency (POI) is characterized by cessation of menstruation before 40 years of age and elevated serum level of FSH (>25 IU/L). Recent studies have found a few causative genes responsible for POI enriched in meiotic recombination and DNA damage repair pathways. OBJECTIVE: To investigate the role of variations in homologous recombination genes played in POI pathogenesis. METHODS:...

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PMID: 32772095
DOI: 10.1210/clinem/dgaa505

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