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Article

Haploinsufficiency in non-homologous end joining factor 1 induces ovarian dysfunction in humans and mice

22 Apr 2021

Abstract excerpt

Background Premature ovarian insufficiency (POI) is a common disease in women that leads to a reduced reproductive lifespan. The aetiology of POI is genetically heterogeneous, with certain double-strand break (DSB) repair genes being implicated in POI. Although non-homologous end joining (NHEJ) is an efficient DSB repair pathway, the functional relationship between this pathway and POI remains unknown. Methods...

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PMID: 33888552
DOI: 10.1136/jmedgenet-2020-107398

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