Article
Assessment of systemic genetic damage in pediatric inflammatory bowel disease.
Environmental and molecular mutagenesis - 1 Nov 2020
Baig Ayesha, Avlasevich Svetlana L, Torous Dorothea K, Bemis Jeffrey C, Saubermann Lawrence J, Lovell David P, MacGregor James T, Dertinger Stephen D
Abstract excerpt
The etiology of distal site cancers in inflammatory bowel disease (IBD) is not well understood and requires further study. We investigated whether pediatric IBD patients' blood cells exhibit elevated levels of genomic damage by measuring the frequency of mutant phenotype (CD59-/CD55-) reticulocytes (MUT RET) as a reporter of PIG-A mutation, and the frequency of micronucleated reticulocytes (MN-RET) as an...
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