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Article

Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore.

International journal of molecular sciences - 4 Aug 2020

Koga Hitomi, Negishi Mai, Kinoshita Marie, Fujii Shinya, Mori Shuichi, Ishigami-Yuasa Mari, Kawachi Emiko, Kagechika Hiroyuki, Tanatani Aya

Abstract excerpt

First-generation nonsteroidal androgen receptor (AR) antagonists, such as flutamide (2a) and bicalutamide (3), are effective for most prostate cancer patients, but resistance often appears after several years due to the mutation of AR. Second-generation AR antagonists are effective against some of these castration-resistant prostate cancers, but their structural variety is still limited. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32759847
DOI: 10.3390/ijms21155584
PMCID: PMC7432827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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