Article
Increased risk of occupational trichloroethylene hypersensitivity syndrome at exposure levels higher than 15 mg/L of urinary trichloroacetic acid, regardless of whether the patients had the HLA-B*13:01 allele.
Environmental research - 1 Dec 2020
Wang Hailan, Nakajima Tamie, Ito Yuki, Naito Hisao, Zhao Na, Li Hongling, Qiu Xinxiang, Xia Lihua, Chen Jiabin, Wu Qifeng, Li Laiyu, Huang Hanlin, Yanagiba Yukie, Qu Hongyung, Yatsuya Hiroshi, Kamijima Michihiro
Abstract excerpt
Occupational trichloroethylene (TCE) exposure can cause hypersensitivity syndrome (TCE-HS). The human leukocyte antigen (HLA)-B*13:01 is reportedly an important allele involved in TCE-HS onset. However, the threshold exposure level causing TCE-HS in relation to HLA-B*13:01 remains unknown. We conducted a case-control study comprising 37 TCE-HS patients and 97 age- and sex-matched TCE-tolerant controls from the...
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