Article
Computed Tomography-based Airway Surface Area-to-Volume Ratio for Phenotyping Airway Remodeling in Chronic Obstructive Pulmonary Disease.
American journal of respiratory and critical care medicine - 15 Jan 2021
Bodduluri Sandeep, Kizhakke Puliyakote Abhilash, Nakhmani Arie, Charbonnier Jean-Paul, Reinhardt Joseph M, Bhatt Surya P
Abstract excerpt
Rationale: Airway remodeling in chronic obstructive pulmonary disease (COPD) is due to luminal narrowing and/or loss of airways. Existing computed tomographic metrics of airway disease reflect only components of these processes. With progressive airway narrowing, the ratio of the airway luminal surface area to volume (SA/V) should increase, and with predominant airway loss, SA/V should decrease.Objectives: To...
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