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Article

An unexpected new role of mutant Ras: perturbation of human embryonic development.

Journal of molecular medicine (Berlin, Germany) - 1 Mar 2007

Kratz Christian P, Niemeyer Charlotte M, Zenker Martin

Abstract excerpt

The Ras signaling pathway controls important cellular responses to growth factors, and somatic mutations in RAS genes and other components of the Ras pathway, such as PTPN11 (encoding the protein-tyrosine phosphatase SHP-2) and BRAF, are found in human malignancies. Ras proteins are guanosine nucleotide-binding proteins that cycle between active guanosine triphosphate (GTP)-bound and inactive guanosine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17211612
DOI: 10.1007/s00109-006-0135-4
PMCID: PMC1820751

Genes

BRAF
HRAS
KRAS
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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