Article
MYBPC3 Haplotype Linked to Hypertrophic Cardiomyopathy in Rhesus Macaques (Macaca mulatta).
Comparative medicine - 1 Oct 2020
Oldt Robert F, Bussey Kimberly J, Settles Matthew L, Fass Joseph N, Roberts Jeffrey A, Reader J Rachel, Komandoor Srivathsan, Abrich Victor A, Kanthaswamy Sreetharan
Abstract excerpt
In humans, abnormal thickening of the left ventricle of the heart clinically defines hypertrophic cardiomyopathy (HCM), a common inherited cardiovascular disorder that can precede a sudden cardiac death event. The wide range of clinical presentations in HCM obscures genetic variants that may influence an individual's susceptibility to sudden cardiac death. Although exon sequencing of major sarcomere genes can be...
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