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Targeting p53 for the treatment of cancer

31 Jul 2020

Abstract excerpt

Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two principal mechanisms are responsible for this dysfunction; mutation and downregulation of wild-type p53 mediated by MDM2/MDM4. Because of its almost universal inactivation in malignancy, p53 is a highly attractive target for the development of new anticancer drugs. Although multiple strategies have been investigated for targeting...

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PMID: 32741700
DOI: 10.1016/j.semcancer.2020.07.005

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