Diversity analysis at MHC class II DQA locus in buffalo (Bubalus bubalis) indicates extensive duplication and trans-species evolution.

doi:10.1016/j.ygeno.2020.07.041

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Article

Diversity analysis at MHC class II DQA locus in buffalo (Bubalus bubalis) indicates extensive duplication and trans-species evolution.

Genomics - 1 Nov 2020

Mishra Shailendra Kumar, Niranjan Saket Kumar, Singh Ravinder, Kumar Prem, Kumar S Lava, Banerjee Bhaswati, Kataria Ranjit Singh

Abstract excerpt

Variation at MHC Class II-DQA locus in riverine and swamp buffaloes (Bubu) has been explored in this study. Through sequencing of buffalo DQA, 48 nucleotide variants identified from 17 individuals, reporting 42 novel alleles, including one pseudogene. Individual animal displayed two to seven variants, suggesting the presence of more than two Bubu-DQA loci, as an evidence of extensive duplication. dN values were...

Topics

Alleles
Animals
Buffaloes
Cattle
Evolution, Molecular
Gene Conversion
Gene Duplication
Genes, MHC Class II
Genetic Loci
Genetic Variation
Genotyping Techniques
Phylogeny

Source

Open in PubMed

Identifiers

PMID: 32738270
DOI: 10.1016/j.ygeno.2020.07.041

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