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Article

Alcohol Use Is Associated With Intestinal Dysbiosis and Dysfunctional CD8+ T-Cell Phenotypes in Persons With Human Immunodeficiency Virus.

The Journal of infectious diseases - 29 Mar 2021

Maffei Vincent J, Siggins Robert W, Luo Meng, Brashear Meghan M, Mercante Donald E, Taylor Christopher M, Molina Patricia, Welsh David A

Abstract excerpt

BACKGROUND: Inflammation persists among persons with human immunodeficiency virus (PWH) despite effective antiretroviral therapy and may contribute to T-cell dysfunction. Alcohol use is prevalent among PWH and promotes intestinal leak, dysbiosis, and a proinflammatory milieu. Whether alcohol use is associated with T-cell late differentiation remains to be investigated. METHODS: Data and samples from PWH (N = 359...

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Identifiers

PMID: 32725203
DOI: 10.1093/infdis/jiaa461
PMCID: PMC8006423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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