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Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

28 Jul 2020

Abstract excerpt

BACKGROUND: Vaccines to prevent coronavirus disease 2019 (Covid-19) are urgently needed. The effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines on viral replication in both upper and lower airways is important to evaluate in nonhuman primates. METHODS: Nonhuman primates received 10 or 100 μg of mRNA-1273, a vaccine encoding the prefusion-stabilized spike protein of SARS-CoV-2, or no...

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PMID: 32722908
DOI: 10.1056/nejmoa2024671

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